You still need to track down the safe combinations from each level first. All safe codes in Dishonored 2 change each time you play, so it isn't a matter of memorizing them for when you find the safe.
But each time you go for a replay, you'll have to crack Dishonored 2 safe codes yet again. It is always tempting after finishing a playthrough to dive back in and try a different chaos level or switch protagonists. Updated June 19, 2023, by Luke Ackroyd: Dishonored 2 is a fantastic game that you can spend hours and hours playing due to the variety in which you can complete each mission. They just require a keen eye to spot them. Luckily, the codes are never too far away. You will need to track down these safe code locations first unless you want to try brute-forcing your way into each safe (and turn Dishonored 2 into a safe-cracking simulator instead). Unfortunately, these codes are usually randomized.